Earth Science News  





. Compound May Prevent Neuron-Degeneration

Nagoya, Japan (UPI) Sep 14, 2005
Scientists from Japan's Nagoya University School of Medicine say they've found a chemical compound that prevents a neuron-degeneration process.

The researchers, writing in the journal Nature Medicine, said the compound known as 17-AAG might be used as a molecular targeted drug, the Asahi Shimbun reported Tuesday.

"The concept of molecular targeted drugs is an important one for developing new drug therapies for neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease," said Gen Sobue, who led the research team.

Neuron degeneration is linked to the accumulation of mutant proteins in nerve cells and experiments have confirmed 17-AAG has a special effect on such proteins, the newspaper reported.

The researchers said the compound lies dormant when there is nothing unusual about a certain part of the protein receptor. But when abnormalities develop the compound functions to inhibit and degrade the suspect protein, Asahi Shimbun said.

Molecular targeted drugs are a focus of research in cancer prevention, and 17-AAG has been considered a possible chemical compound for use in such drugs.

All rights reserved. © 2005 United Press International. Sections of the information displayed on this page (dispatches, photographs, logos) are protected by intellectual property rights owned by United Press International. As a consequence, you may not copy, reproduce, modify, transmit, publish, display or in any way commercially exploit any of the content of this section without the prior written consent of United Press International.

Related Links
TerraDaily
Search TerraDaily
Subscribe To TerraDaily Express

Parts Of Brain Battle Over Decisions
Stanford, Calif. (UPI) Sep 01, 2005
Researchers have identified areas in the brain that anticipate joy and fear and say they battle it out when a big decision is to be made.
.
Get Our Free Newsletters Via Email