by Staff Writers
Washington DC (SPX) Apr 08, 2016
Researchers reporting in the American Journal of Human Genetics, published by Cell Press, have completed the first in-depth genetic analysis of a Neanderthal Y chromosome. The findings offer new insights into the relationship between Neanderthals and modern humans and some of the genetic factors that might have kept the two lineages apart.
The Y chromosome was the main component remaining to be analyzed from the Neanderthal genome, the researchers say.
"Characterizing the Neanderthal Y chromosome helps us to better understand the population divergence that led to Neanderthals and modern humans," says Fernando Mendez of Stanford University. "It also enables us to explore possible genetic interactions between archaic and modern [gene] variants within hybrid offspring."
Mendez and his colleagues, including Carlos Bustamante, also at Stanford, and Sergi Castellano, from the Max Planck Institute for Evolutionary Anthropology in Germany, analyzed the Y chromosome from a Neanderthal male found in El Sidron, Spain. Their analysis suggests that Neanderthals and modern humans diverged almost 590,000 years ago, consistent with earlier evidence.
The researchers say that the Neanderthal Y chromosome they sequenced is distinct from any Y chromosome observed in modern humans, suggesting that the lineage in question is to be extinct. They also found some intriguing protein-coding differences between genes on the Neanderthal and modern human Y chromosomes.
Three of those changes are missense mutations in genes known in humans to produce male-specific minor histocompatibility antigens. Antigens derived from one of these genes, known as KDM5D, are thought to elicit an immune response in some pregnant mothers against their male fetuses and lead to miscarriages.
The researchers speculate that incompatibilities at one or more of these genes might have played a role in driving ancient humans and Neanderthals apart by discouraging interbreeding between them.
"The functional nature of the mutations we found suggests to us that the Y chromosome may have played a role in barriers to gene flow," Bustamante says.
"The finding that most of the functional differences associate with these genes, rather than with genes involved in [sperm production], came as a surprise," Mendez adds.
The researchers say additional research is required to confirm the role of those Y-chromosome mutations in discouraging the formation of a hybrid Neanderthal and human species. They are planning those experiments now.
The authors were supported by the National Science Foundation; the Stanford Center for Computational, Evolutionary, and Human Genomics; the National Library of Medicine; and the Max Planck Society. American Journal of Human Genetics, Mendez et al.: "The divergence of Neanderthal and modern human Y chromosomes'
All About Human Beings and How We Got To Be Here
|The content herein, unless otherwise known to be public domain, are Copyright 1995-2017 - Space Media Network. All websites are published in Australia and are solely subject to Australian law and governed by Fair Use principals for news reporting and research purposes. AFP, UPI and IANS news wire stories are copyright Agence France-Presse, United Press International and Indo-Asia News Service. ESA news reports are copyright European Space Agency. All NASA sourced material is public domain. Additional copyrights may apply in whole or part to other bona fide parties. All articles labeled "by Staff Writers" include reports supplied to Space Media Network by industry news wires, PR agencies, corporate press officers and the like. Such articles are individually curated and edited by Space Media Network staff on the basis of the report's information value to our industry and professional readership. Advertising does not imply endorsement, agreement or approval of any opinions, statements or information provided by Space Media Network on any Web page published or hosted by Space Media Network. Privacy Statement|