Free Newsletters - Space - Defense - Environment - Energy - Solar - Nuclear
..
. Earth Science News .




FLORA AND FAUNA
25 years of DNA on the computer
by Staff Writers
Rome, Italy (SPX) Jan 06, 2014


This image shows a DNA computer simulation. Credit: credits: SISSA. source: Angelo Rosa and Ralf Everaers, Plos Computational Biology 4, e1000153 (2008).

DNA carries out its activities "diluted" in the cell nucleus. In this state it synthesises proteins and, even though it looks like a messy tangle of thread, in actual fact its structure is governed by precise rules that are important for it to carry out its functions.

Biologists have studied DNA by observing it experimentally with a variety of techniques, which have only recently been supplemented by research in silico, that is to say, the study of DNA by means of computer simulations.

This is a recent area of study, but it has already given a major contribution to knowledge in this field. Angelo Rosa, a theoretical physicist of the International School for Advanced Studies (SISSA) in Trieste, with the collaboration of Christophe Zimmer, an experimental physicist from the Pasteur Institute in Paris has assessed the state of the art of this novel but powerful approach in a systematic review that has just been published in the journal International Review of Cell and Molecular Biology.

"Apart from some rare exceptions, we reviewed virtually all of the models developed to date", explains Rosa.

"The review is mainly aimed at biologists in that we have made minimal use of mathematical formulas which hamper reading. I think this is the first review of its kind. The paper is actually also interesting for physicists and mathematicians who are approaching this new field for the first time".

The two physicists reviewed 25 years of computational models: "in this relatively short time span the models have become increasingly sophisticated and this, thanks to the development of computers", explains Rosa.

"Today we are able to make far more detailed and predictive simulations, which allow us to lead the work of experimental researchers in previously unthought-of directions".

"This is a useful tool which, without going into mathematical detail, provides the biologist with an overview of the type of studies that will increasingly complement the more traditional approaches" continues Rosa.

"Today, for example, we already have software programmes which, starting from experimental data, allow us to reconstruct the structure of specific portions of chromosomes. I think that if computers continue to evolve as they have done until now - and there's no reason to doubt this - we'll be able to reconstruct entire chromosomes".

"At the present time, the future prospects of in silico research into nuclear DNA are twofold", concludes Rosa, "to understand in detail the dynamics of gene expression (the details of protein synthesis) and to identify precisely where the chromosomes are when DNA unravels in the nucleus".

.


Related Links
International School of Advanced Studies (SISSA)
Darwin Today At TerraDaily.com






Comment on this article via your Facebook, Yahoo, AOL, Hotmail login.

Share this article via these popular social media networks
del.icio.usdel.icio.us DiggDigg RedditReddit GoogleGoogle




Memory Foam Mattress Review
Newsletters :: SpaceDaily :: SpaceWar :: TerraDaily :: Energy Daily
XML Feeds :: Space News :: Earth News :: War News :: Solar Energy News





UAV Payloads 2014, 24 - 25 June - London, UK
FLORA AND FAUNA
Reproduction matters for microbes
Bristol UK (SPX) Jan 06, 2014
Caught in the act! Researchers from the University of Bristol have observed mating for the first time in the microbes responsible for African sleeping sickness. This tropical disease is caused by trypanosomes, single-celled parasites that are found in the blood of those afflicted. The Bristol team were able to see what the trypanosomes were getting up to inside the tsetse flies that carry ... read more


FLORA AND FAUNA
Four arrested over Italy quake contract bribes

Philippine inflation jumps following Haiyan

System of phone alerts could warn of extreme weather in India

'Village of Widows' determined to rebuild in India flood disaster

FLORA AND FAUNA
Computers search for 'cheapium' versions of expensive materials

New computer memory can hold data 20 years without power

AVX Announces Market Introduction of First Space-Level BME MLCC

3D-printed components flown in British fighter jet

FLORA AND FAUNA
Norway says working to end Russian boycott on fish exports

Melanin in marine fossils offers clues about where they could survive

Scientists off to Pacific to study 'weather chimney' effect on climate

For sharks, old age may be 70 or more: study

FLORA AND FAUNA
Antarctic mission over as ships clear ice field

Trapped ships break through Antarctic ice

Chinese icebreaker shines spotlight on polar ambitions

US icebreaker heads to Antarctic to help stuck ships

FLORA AND FAUNA
Over 350 sick in Japan after eating pesticide-tainted food: NHK

New study may aid rearing of stink bugs for biological control

Important mutation discovered in dairy cattle

Chinese scientists create high-yield, salt-resistant rice variety

FLORA AND FAUNA
Texas to hire seismologist to study if quakes, energy production tied

Longmanshen fault zone still hazardous

One dead as cyclone skims France's Reunion island

Indonesian volcano erupts 30 times as 20,000 displaced

FLORA AND FAUNA
Colonel Ndala: slain hope of reformed DR Congo army

A year after Mali action, France remains 'Africa's gendarme'

French defence minister sees no need for more troops in C. Africa

Fighting across South Sudan despite peace talks: army

FLORA AND FAUNA
Money Talks When Ancient Antioch Meets Google Earth

Reading a good book may make permanent changes to your brain

Finnish research team reveals how emotions are mapped in the body

What Does Compassion Sound Like?




The content herein, unless otherwise known to be public domain, are Copyright 1995-2014 - Space Media Network. AFP, UPI and IANS news wire stories are copyright Agence France-Presse, United Press International and Indo-Asia News Service. ESA Portal Reports are copyright European Space Agency. All NASA sourced material is public domain. Additional copyrights may apply in whole or part to other bona fide parties. Advertising does not imply endorsement,agreement or approval of any opinions, statements or information provided by Space Media Network on any Web page published or hosted by Space Media Network. Privacy Statement