by Staff Writers
Worcester MA (SPX) Jun 22, 2011
For migratory birds and sea turtles, the ability to sense the Earth's magnetic field is crucial to navigating the long-distance voyages these animals undertake during migration. Humans, however, are widely assumed not to have an innate magnetic sense.
Research published in Nature Communications this week by faculty at the University of Massachusetts Medical School shows that a protein expressed in the human retina can sense magnetic fields when implanted into Drosophila, reopening an area of sensory biology in humans for further exploration.
In many migratory animals, the light-sensitive chemical reactions involving the flavoprotein cryptochrome (CRY) are thought to play an important role in the ability to sense the Earth's magnetic field.
In the case of Drosophila, previous studies from the Reppert laboratory have shown that the cryptochrome protein found in these flies can function as a light-dependent magnetic sensor.
To test whether the human cryptochrome 2 protein (hCRY2) has a similar magnetic sensory ability, Steven Reppert, MD, the Higgins Family Professor of Neuroscience and chair and professor of neurobiology, graduate student Lauren Foley, and Robert Gegear, PhD, a post doctoral fellow in the Reppert lab now an assistant professor of biology and biotechnology at Worcester Polytechnic Institute, created a transgenic Drosophila model lacking its native cryptochrome protein but expressing hCRY2 instead.
Using a behavioral system Reppert's group previously developed, they showed that these transgenic flies were able to sense and respond to an electric-coil-generated magnetic field and do so in a light-dependent manner.
These findings demonstrate that hCRY2 has the molecular capability to function in a magnetic sensing system and may pave the way for further investigation into human magnetoreception.
"Additional research on magneto sensitivity in humans at the behavioral level, with particular emphasis on the influence of magnetic field on visual function, rather than non-visual navigation, would be informative," wrote Reppert and his colleagues in the study.
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Family genetic research reveals the speed of human mutation
Montreal, Canada (SPX) Jun 20, 2011
A team of researchers have discovered that, on average, thirty mutations are transmitted from each parent to their child, revising previous estimations and revolutionizing the timescale we use to calculate the number of generations separating us from other species. "Your genome, or genetic code, is made up of six billion pieces of information, called nucleotides," explained co-lead author ... read more
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