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H7N9 bird flu can spread in mammals: study
by Staff Writers
Washington (AFP) May 23, 2013

WHO voices deep concern over spread of SARS-like virus
Geneva (AFP) May 23, 2013 - The World Health Organization voiced deep concern Thursday over the SARS-like virus that has killed 22 people in less than a year, saying it might potentially spread more widely between humans.

"We have a high level of concern over the potential... for this virus to have sustainable person-to-person spread," WHO deputy chief Keiji Fukuda told diplomats gathered in Geneva for the World Health Assembly, the UN agency's decision-making body.

There has already been evidence of limited transmission between humans, and last week the WHO said two Saudi health workers had contracted the deadly coronavirus from patients -- the first evidence of transmission in a hospital setting.

But Fukuda said the WHO was looking into "whether this has the potential to have a more extensive spread, more extensive transmission."

Given the high fatality rate relative to the number of cases, experts have highlighted the power of the virus and the frightening prospect of its mutating into a form that leaps easily from human to human.

Fukuda's comments came after Saudi Arabia on Wednesday said another person had died from the virus. With a total death toll of 17, it has been the hardest hit by the disease that first emerged last June.

So far, there have been 44 lab-confirmed cases worldwide, half of them fatal, with 30 infections in Saudi Arabia and the rest spread across Jordan, Qatar, Tunisia, the United Arab Emirates, Germany, Britain and France.

Most of the patients infected in Europe and Tunisia had links to or had travelled in the Middle East.

The WHO said Thursday the virus, which until now has been known as the novel coronavirus, or nCoV-EMC, had been redubbed the Middle East Respiratory Syndrome Coronavirus (MERS CoV).

The virus is a cousin of Severe Acute Respiratory Syndrome (SARS), which triggered a scare 10 years ago when it erupted in east Asia, leaping to humans from animal hosts and eventually killing some 800 people.

Like SARS, the new virus appears to cause an infection deep in the lungs, with patients suffering from a temperature, cough and breathing difficulty, but it differs from SARS in that it also causes rapid kidney failure.

The H7N9 strain of bird flu can spread among ferrets and could do the same among humans under certain conditions, according to lab animal studies on the virus published Thursday.

So far there have been no known cases of human-to-human spread of the new virus, which has infected 131 people and killed 36 since it first emerged in China in March.

If the virus were found to be able to spread easily among humans, experts fear it could trigger a widespread pandemic. Animal studies are a first step toward understanding how easily the virus might spread in people.

"The emerging human H7N9 influenza is infectious and transmissible in mammals," said the study in the US journal Science led by researchers at Shantou University, the University of Hong Kong and co-authored by colleagues in the US and Canada.

"Under appropriate conditions, human-to-human transmission of the H7N9 virus may be possible," the study added.

Scientists infected lab ferrets with a sample of H7N9 taken from one of the people who died from it, and found that the virus spread among ferrets in direct contact, said the report.

The virus was also found to be transmissible by air, though just one of the three ferrets tested became ill in this way.

The study also tested pigs, which are considered even closer than ferrets to humans, and found that pigs could become infected but that they did not pass the virus to each other.

"If the study has shown that one pig had easily infected another pig, then I would be more concerned," said Anthony Fauci, head of the US National Institute of Allergy and Infectious Diseases.

Fauci, who was not involved in the research, said the findings should be interpreted with caution.

"Under very experimental circumstances, one mammal can infect another one by direct contact," he told AFP.

"Saying that we are now in a greater danger of a pandemic is probably an exaggeration," he added. "It's obviously something we need to keep an eye on to make sure we understand the virus better."

Ferrets that were infected did not show symptoms of illness right away, even though they had the virus in their nasal secretions, which the study authors noted was typical in pandemic and seasonal influenza.

After the infected animals were autopsied, the virus was found to be replicating in the upper as well as the lower respiratory tract, and viral RNA was detected in the ferrets' trachea, lungs, lymph nodes and brains.

"It seemed significant to me that that much virus is reaching the brain," said Suresh Mittal, a bird flu expert and professor of comparative pathology at Purdue University.

Mittal, who was not involved in the research, said that it is not unusual for certain highly pathogenic viruses to reach the brain, but it is not often seen in human flu pandemics and more research is needed.

"Physicians will be more careful looking at patients and seeing if patients develop signs of encephalitis or not," he told AFP.

Some symptoms might include confusion, dizziness, severe headache and neck pain, he said.

Overall, Mittal said the study appeared to be well done and offered important signs about the transmissibility of the virus.

"The virus seems dangerous because it does infect humans and even in the pigs the virus comes out in nasal secretions," he said.

"The main thing is how to keep this away from the pig, which is a mixing vessel."

He said that poultry and pig farms are typically kept separate in North America and Europe, lowering the likelihood that an avian influenza could emerge and jump to a pig host and eventually infect humans.

"But in China they may not be separate, so there the chances of getting the avian virus from poultry into pigs is much easier," he said.


Related Links
Epidemics on Earth - Bird Flu, HIV/AIDS, Ebola

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