Subscribe free to our newsletters via your
. Earth Science News .

Less-used drug better treats HIV in kids: study
by Staff Writers
Washington (AFP) April 30, 2013

The antiretroviral drug efavirenz is more effective at treating children infected with HIV than the more commonly used and cheaper nevirapine, according to a study out Tuesday.

The study is being billed as the first large-scale comparison of first-line treatments for HIV-positive children, and could have an impact on care in poor parts of the world, where most of them live.

Published in the Journal of the American Medical Association, the findings show initial treatment with efavirenz was more effective than nevirapine in suppressing the virus that causes AIDS in children aged three to 16.

The study involved more than 800 children, and was carried out by researchers from the Children's Hospital of Philadelphia, the Perelman School of Medicine at the University of Pennsylvania and the Botswana-Baylor Children's Clinical Center of Excellence.

The World Health Organization currently recommends both efavirenz and nevirapine in poor areas like sub-Saharan Africa, home to 90 percent of the world's more than three million HIV-positive children.

"Because nevirapine costs less than efavirenz and is more widely available in pediatric formulations, it is currently the more frequent choice," said lead author Elizabeth Lowenthal, of the Children's Hospital of Philadelphia.

"However, our study suggests that efavirenz produces better outcomes."

Senior author Robert Gross of Penn Medicine said that, given the evidence, it was "very reasonable to adjust pediatric treatment guidelines."

"However, as we move towards such changes, more work should be done to make efavirenz a more financially viable option for children on antiretroviral therapy in these resource-limited settings," he added.

Several previous studies have shown efavirenz to be more effective in adults, leading to it being recommended over nevirapine in a number of countries.

Nevirapine is produced by Boehringer Ingelheim, while efavirenz is marketed under the name Sustiva in the United States by Bristol-Myers Squibb.


Related Links
Epidemics on Earth - Bird Flu, HIV/AIDS, Ebola

Comment on this article via your Facebook, Yahoo, AOL, Hotmail login.

Share this article via these popular social media networks DiggDigg RedditReddit GoogleGoogle

Memory Foam Mattress Review
Newsletters :: SpaceDaily :: SpaceWar :: TerraDaily :: Energy Daily
XML Feeds :: Space News :: Earth News :: War News :: Solar Energy News

China reports 24th death from new bird flu
Beijing (AFP) April 29, 2013
The deadly H7N9 bird flu strain claimed a new victim on Monday when a hospital patient died in China, state media reported, bringing the death toll from the recently identified virus to 24. A patient surnamed Chen died in the eastern city of Shanghai after 12 days of medical treatment failed, Xinhua news agency said. China has recorded more than 120 cases of H7N9 infection so far. Most c ... read more

Hong Kong ferry disaster report finds 'litany of errors'

Ukraine marks Chernobyl disaster amid efforts to secure reactor

U.S. lawyer defends Australian asylum seekers

Landslide kills 14 in Ecuador

Astronaut Finds 'Bullet Hole' in ISS Solar Panel

More videogame players moving online: survey

Videogames slow, reverse 'mental decay': study

Older Is Wiser: Study Shows Software Developers' Skills Improve Over Tim

Sea Turtles Benefiting From Protected Areas

Greece water company receives privatisation bids

Scientists to replenish lobster population with help from wind farm

Sea Surface Temperatures Reach Highest Level in 150 Years on Northeast Continental Shelf

UN sounds alarm over record Arctic ice melt

Discovered: A mammal and bug food co-op in the High Arctic

EU spars with Canada, Norway at WTO over seal ban

EU court maintains seal fur ban

China children killed with poisoned yoghurt: Xinhua

Electron-beam pasteurization of raw oysters may reduce viral food poisoning

Fertilizers provide mixed benefits to soil in 50-year Kansas study

Study: Traditional ranching helps, not hurts, African ecosystems

Saudi floods death toll rises to 20: civil defence

Flash floods in Saudi kill 16: civil defence

Earthquake rattles buildings in northern India

Two dead as quake shakes northern India

Questions in S.Africa after Zuma's rich friends use military base

S.Africa army death toll in Central Africa rises to 14

Sudan state declared rebel 'target' as aviation warned

Bouteflika stroke triggers Algerian crisis

CNIO researchers 'capture' the replication of the human genome for the first time

For ancient Maya, a hodgepodge of cultural exchanges

Genetic circuit allows both individual freedom, collective good

As people live longer and reproduce less, natural selection keeps up

The content herein, unless otherwise known to be public domain, are Copyright 1995-2014 - Space Media Network. AFP, UPI and IANS news wire stories are copyright Agence France-Presse, United Press International and Indo-Asia News Service. ESA Portal Reports are copyright European Space Agency. All NASA sourced material is public domain. Additional copyrights may apply in whole or part to other bona fide parties. Advertising does not imply endorsement,agreement or approval of any opinions, statements or information provided by Space Media Network on any Web page published or hosted by Space Media Network. Privacy Statement