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Paris spotlight on latest in AIDS science
By Mariėtte Le Roux
Paris (AFP) July 21, 2017

AIDS in 10 dates
Paris (AFP) July 21, 2017 - From the start of the AIDS epidemic in 1981, here are 10 dates in the history of the disease.

- 1981: First alert -

On June 5, 1981, US epidemiologists report the first deaths among young homosexuals from a mysterious immune-wrecking disease later named acquired immune deficiency syndrome (AIDS).

The Center for Disease Control (CDC) later identifies the same infections among injected drug-users (late 1981), haemophiliacs (mid 1982) and Haitian residents in the US (mid 1982).

The term AIDS appears in 1982.

- 1983: identifying HIV -

In January 1983, researchers in France, Francoise Barre-Sinoussi and Jean-Claude Chermann under the direction of Luc Montagnier, identify the virus that "might be" responsible for AIDS. It is dubbed LAV.

The next year, US specialist Robert Gallo is said to have found the "probable" cause of AIDS, a retrovirus dubbed HTLV-III.

The two viruses turn out to be one and the same, and in May 1986 it becomes officially known as the human immunodeficiency virus, or HIV.

- 1987: AZT -

On March 20, 1987, the first anti-retroviral treatment known as AZT is authorised in the US. It is expensive and has many side effects however.

- 1988: First AIDS day -

December 1, 1988 is established by the World Health Organisation (WHO) as the first World AIDS Day.

In June 1989 the number of AIDS cases worldwide is estimated at more than 150,000.

- Early 90s: Falling stars -

US actor Rock Hudson is the first high-profile AIDS victim in October 1985. In the early 1990s other stars succumb to the disease, notably British singer Freddie Mercury in November 1991 and Russian dancer-choreographer Rudolf Nureyev in January 1993.

The next year, AIDS becomes the leading cause of death among US citizens aged 24-44.

- 1995/96: new approach -

In 1995/96, a new approach begins with the advent of new anti-retroviral therapies, and drug combinations that provide the first effective treatment for HIV although they are not a cure.

In the US, 1996 is the first year during which the number of AIDS deaths declines.

- 1999: 50 million -

A report released by WHO and the Joint United Nations Programme on AIDS (UNAIDS) in November 1999 estimates the number of people infected with HIV since it first appeared at 50 million, of whom 16 million died.

Africa is the hardest-hit continent, with 12.2 million cases.

- 2001: generic treatments -

Following an accord signed in 2000 by UNAIDS and major pharmaceutical firms to make treatment affordable in poor countries, the World Trade Organisation hosts the signing of a compromise on November 13, 2001 that allows developing countries to produce generic treatments.

- 2008: Nobel Prize -

On October 6, 2008, the Nobel Prize in Physiology or Medicine is awarded to Barre-Sinoussi and Montagnier "for their discovery of human immunodeficiency virus".

- 2012: Preventive treatment -

On July 16, 2012, the anti-retroviral treatment Truvada is approved for use in the US as a preventive tool to help ward off HIV.

Some 6,000 HIV experts gather in Paris from Sunday to report advances in AIDS science as fading hopes of finding a cure push research into new fields.

In their 36-year battle, researchers have always come up short against the virus' guerrilla tactics -- hiding out in human cells and playing dead only to reemerge and attack as soon as treatment is stopped.

Today's research is about finding ways to keep the virus dormant with as few drugs and side-effects as possible.

And, of course, better ways to prevent infection in the first place.

"Eradicating the virus from someone, where you completely get rid of every single viral particle, is very difficult, if not impossible," said AIDS expert Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases (NIAID) -- a branch of the US government's National Institutes of Health (NIH).

"So what we're focusing more on is... called an ART-free remission," he told AFP -- using the acronym for anti-retroviral therapy.

The new buzzword is "functional cure".

Unlike a traditional cure, where the virus is eradicated, the patient would still have HIV in their system.

But the virus would be so weakened that it cannot replicate, or spread to sexual partners, for a prolonged period of time -- researchers hope permanently -- without the need for daily drugs.

Though much improved since their revolutionary arrival in the 1990s, anti-retrovirals have side-effects which can include diarrhoea, skin rashes, nausea, insomnia and headaches.

And providing a lifelong supply to millions of people is a costly affair.

The World Health Organization (WHO) recommends ART for every one of the 36.7 million people living with HIV today. By 2016, some 19.5 million were getting it, according to UNAIDS.

- 'Almost everybody rebounds' -

The cost of treatment, in poor countries, ranges from $85 (74 euros) per person per year, to over $1,200 in cases where the first line of available drugs fail to work.

Worried specialists say the need to switch treatment is now more common as the virus becomes resistant to first-choice medication.

"We cannot afford to keep funding an epidemic of this proportion," said Linda-Gail Bekker, HIV vaccine researcher and president of the International AIDS Society hosting the conference in Paris, where lab scientists in 1983 identified the discovered the virus that causes AIDS.

"The long-term plan is if we can reduce our treatment pool... through remission, then that will be fantastic," she added.

Among the many promising, but as-yet-elusive strategies being probed, is getting people on medication as soon as possible after infection -- seemingly the best hope, especially in newborns, for long-term remission.

Other hopeful possibilities include injections of virus-fighting antibodies, boosting the patient's own immune system with a so-called therapeutic vaccine, or long-acting injectable forms of ARV, experts say.

Only a few people have achieved drug-free remission to date.

They include a group of 14 patients started on drugs in a French trial within 10 weeks of infection, who were able to stop after three years and have stayed healthy for several years since then.

Two years ago, a French teenager was reported to have been in remission for 12 years after stopping her medication.

In the United States, the so-called Mississippi Baby was in remission for 27 months after being given ART for the first 18 months of life, but the virus rebounded in a major let-down for researchers.

"People are realising that no matter what you do, for the most part.... when you stop therapy almost everybody rebounds," said Fauci.

- HIV is not over -

Another research priority is prevention.

As work on a vaccine -- the holy grail -- continues furiously in several countries simultaneously, much research is dedicated to the more immediate challenge of reducing infection through sex.

A far cry from the ABC (Abstain, Be faithful, Condomise) message of the 1990s, the new angle of attack includes such interventions as drug-doused vaginal rings and male circumcision to limit virus spread.

And then there is PrEP -- short for pre-exposure prophylaxis, which involves healthy people taking ARVs as protection.

It is an expensive option, but early trials have shown it does lower the risk.

The July 23-26 conference happens amid concerns that funding for HIV research and treatment programmes may be under threat.

US President Donald Trump has proposed to cut the 2018 NIH budget, for example, and not to increase the life-saving PEPFAR AIDS relief fund.

"Our extraordinary scientific progress against HIV and our ability to address all of the scientific challenges still before us are threatened by a weakening resolve to fund HIV science," said a conference statement.

"HIV is not over," added Bekker.

With 1.8 million new infections last year, bringing to nearly 40 million the number of people who will need life-long treatment, "there is still an epidemic of extraordinary proportions," she said.

"If we take our eye off this ball, we will find ourselves backsliding in scary ways."

Five key numbers on AIDS
Paris (AFP) July 21, 2017 - Someone is infected with the AIDS virus every 17 seconds in the world, and the disease has killed the equivalent of the population of Canada, figures released Thursday by UNAIDS show.

Here is a numerical snapshot of the disease.

- 17 seconds -

Roughly 1.8 million people worldwide contracted the AIDS virus in 2016. That figure breaks down to about one infection by the human immunodeficiency virus (HIV) that causes AIDS every 17 seconds on average, or almost 5,000 per day.

- Two-thirds of new cases in Africa -

Since 2010, the rate of infection among adults has decreased slowly from 1.9 million then to 1.7 million per year in 2016. Two-thirds of new cases occur in Africa.

- Children's cases cut almost by half -

New infections among children have fallen sharply meanwhile, and since 2010 they have been cut almost by half, from 300,000 to 160,000 in 2016.

A key factor has been detection among pregnant women in Africa, followed by treatment with anti retroviral drugs that protect their baby.

- Nearing 40 million with HIV -

Today, close to 40 million people live with the virus. UNAIDS put their number last year at 36.7 million.

The number continues to increase however owing to continued transmission and increased access to anti-retroviral drugs in developing countries that has raised the survival rate of HIV-positive people.

- Deaths halved -

AIDS-related deaths have declined by almost 50 percent since a peak of 1.9 million in 2005, to 1.0 million in 2016.

Almost 20 million people now have access to effective treatment when followed regularly.

An estimated 36 million people have died since the AIDS epidemic erupted in 1981 according to the WHO, roughly equivalent to Canada's population.

As tide turns, AIDS claimed 1 million lives in 2016: UN
Paris (AFP) July 20, 2017
AIDS claimed a million lives in 2016, almost half the 2005 toll that marked the peak of the deadly epidemic, said a UN report Thursday proclaiming "the scales have tipped". Not only are new HIV infections and deaths declining, but more people than ever are on life-saving treatment, according to data published ahead of an AIDS science conference opening in Paris on Sunday. Experts warned, ... read more

Related Links
Epidemics on Earth - Bird Flu, HIV/AIDS, Ebola

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