Traders are also shifting cautiously as they weigh the outlook for US policy post-election, with Democrat chances boosted by the expected nomination of Kamala Harris to replace Joe Biden to battle Donald Trump in November.
Equities have largely been boosted this year by growing expectations that the Federal Reserve will cut interest rates thanks to slowing inflation and a softening of the labour market and officials have indicated lately they are open to a move soon.
The prospect of a more welcoming borrowing environment has heavily benefited tech firms, particularly as they have invested massively in AI, seeing it as the next big money-spinner.
And profits have not disappointed in most cases, helping push their valuations ever higher, with chip titan Nvidia piling on around 150 percent for the year to date.
However, hopes for this earnings cycle were dented slightly Tuesday by news that profits at electric car giant Tesla fell 45 percent in the second quarter owing to price cuts and aggressive AI investment.
And payments behemoth Visa's reported revenue for its fiscal third quarter came in below estimates, though a forecast-beating report from Google-parent Alphabet did provide some support.
Alphabet and Tesla are part of the so-called "Magnificent Seven" tech kings who have been key to driving gains in markets that have pushed Wall Street to multiple record highs in 2024.
The others -- Apple, Amazon, Facebook-parent Meta, Microsoft and Nvidia -- are due to report over the next few weeks.
"The kickoff of earnings season for the 'Magnificent Seven' didn't exactly call for a ticker-tape parade on Wall Street, leaving mega-cap sentiment teetering on a shaky high bar," said Stephen Innes in his Dark Side Of The Boom commentary.
All three main indexes on Wall Street ended slightly lower, and Asia mostly followed suit.
Tokyo, Shanghai, Hong Kong, Sydney, Seoul, Singapore, Mumbai, Bangkok and Jakarta all slipped, though Wellington edged up.
Manila and Taipei were closed because of a typhoon.
London, Paris and Frankfurt all fell in the morning.
Investors are also awaiting the release of key US economic growth data Thursday and the latest reading on personal consumption expenditure -- the Fed's favoured gauge of inflation -- which could play a role in decision-makers' thinking ahead of their next meeting.
But Innes warned: "Markets are wagering that these indicators will give the Fed the green light to take it easy in September. However, any hiccup in the cooling inflation trend could add a plot twist to this Fed soap opera."
Still, PGIM Fixed Income analysts said in a note: "We expect at least one 25-basis-point cut in 2024 with mid-December appearing as the most likely meeting for that decision.
"That said, the Fed could implement another cut in the second half of 2024 if given the opportunity. If the Fed is hindered from cutting rates this year, it could shift those cuts into 2025, and we see a total of 150 basis points in Fed rate cuts through next year."
Bets on a US rate cut continue to weigh on the dollar, particularly against the yen.
The Japanese unit strengthened to around 154.81 to the greenback, extending a recovery after hittting a nearly four-decade low in late June, which led authorities to step in to provide support.
Short-term factors such as economic data and market expectations of future policy shifts at home and abroad "suggest that pressure could soon ease on the embattled currency", said James Brady at Teneo.
But even if the Bank of Japan raises interest rates again in its next meeting, "fresh policy thinking will be needed to ameliorate the long-term factors that are helping depress the yen", he added.
- Key figures around 0810 GMT -
Tokyo - Nikkei 225: DOWN 1.1 percent at 39,154.85 (close)
Hong Kong - Hang Seng Index: DOWN 0.9 percent at 17,311.05 (close)
Shanghai - Composite: DOWN 0.5 percent at 2,901.95 (close)
London - FTSE 100: DOWN 0.5 percent at 8,124.12
Euro/dollar: DOWN at $1.0830 from $1.0855 on Tuesday
Pound/dollar: DOWN at $1.2828 from $1.2907
Dollar/yen: DOWN at 154.60 yen from 155.62 yen
Euro/pound: DOWN at 84.02 pence at 84.08 pence
West Texas Intermediate: UP 0.5 percent at $77.34 per barrel
Brent North Sea Crude: UP 0.5 percent at $81.38 per barrel
New York - Dow: DOWN 0.1 percent at 40,358.09 points (close)
dan/mtp
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